ABSTRACT
To investigate the risk factors for early colorectal cancer in patients with dyslipidemia and the possible role of statins, data of 266 patients with colorectal mass and dyslipidemia who received endoscopic treatment in Beijing Friendship Hospital from February 2018 to February 2021 were collected. The patients were divided into the colorectal adenoma group ( n=174) and the early colorectal cancer group ( n=92) according to colonoscopic and pathological results. Clinical data of the two groups were analyzed. Logistic regression analysis was used to evaluate the risk factors for early colorectal cancer in patients with dyslipidemia. The results showed compared with the colorectal adenoma group, the early colorectal cancer group had a higher proportion of males (64.1% VS 25.9%), smoking (41.3% VS 14.4%) and drinking (37.0% VS 17.2%) and higher low density lipoprotein cholesterol (LDL-C) (3.06±0.81 mmol/L VS 2.60±0.74 mmol/L) and total cholesterol (TC) values (5.27±1.22 mmol/L VS 4.61±1.06 mmol/L), while the proportion of statin use was lower (27.2% VS 52.9%). There were significant differences in the above indices (all P<0.05). Multivariate logistic regression analysis showed that male ( OR=3.641, 95% CI:1.694-7.826), smoking ( OR=2.920, 95% CI:1.159-7.356), higher LDL-C ( OR=2.203,95% CI:1.481-3.277) and higher TC level ( OR=1.744,95% CI:1.329-2.289) were risk factors for early colorectal cancer in patients with hyperlipidemia, while the history of statin use ( OR =0.469, 95% CI: 0.236-0.932) had a protective effect. Smoking cessation education, early screening of LDL-C, TC level, statin use if necessary to reach the standard lipids and screening of early colorectal cancer should be actively carried out in patients with dyslipidemia.